Primary Identifier | MGI:7513806 | Allele Type | Transgenic |
Attribute String | Epitope tag, Inserted expressed sequence | Gene | Tg(Pcp2-ATXN3*69Q)1Hirai |
Strain of Origin | C57BL/6NCrSlc | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The cDNA encoding a N-terminal-truncated form (lacking 286 amino-acid residues) of human ATAXIN-3 with 69 glutamine repeats is driven by a Purkinje-cell specific L7 promoter (Pcp2). The ATG start codon in exon 2 of Pcp2 was mutated to inhibit the expression of exons 1-3. In addition an N-terminal hemagglutinin epitope was added. |