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Allele : Tg(tetO-APPSwInd, KRT14-EGFP)#Dbo transgene insertion, David R Borchelt
Primary Identifier  MGI:7541105 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence, Reporter Gene  Tg(tetO-APPSwInd, KRT14-EGFP)#Dbo
Strain of Origin  FVB/NJ Is Recombinase  false
Is Wild Type  false
molecularNote  The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2.The transgene was co-integrated with a transgene in which the human KRT14 (K14) promoter drives skin-specific expression of EGFP.
  • mutations:
  • Insertion
  • synonyms:
  • moAPPsi-GFP,
  • moAPPsi-GFP
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

2 Publication categories

Trail: Allele




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