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Allele : Tg(Prnp-APPSwInd,KRT14-EGFP)3Dbo transgene insertion 3, David Borchelt
Primary Identifier  MGI:7541068 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence, Reporter Gene  Tg(Prnp-APPSwInd,KRT14-EGFP)3Dbo
Strain of Origin  (C3H/HeJ x C57BL/6J)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The mouse amyloid beta (A4) precursor protein (App) sequence was first modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (called mo/huAPP695 or APP695) was further mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) mutations associated with Alzheimer's disease. This APP695Swe/Ind sequence was placed downstream of the brain-specific mouse prion promoter (Prnp). The transgene was co-integrated with a transgene in which the human KRT14 (K14) promoter drives skin-specific expression of EGFP.
  • mutations:
  • Insertion
  • synonyms:
  • MHSI-695-GFP,
  • MHSI-695-GFP
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele




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