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Allele : Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo transgene insertion D943, David R Borchelt
Primary Identifier  MGI:7541098 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo
Strain of Origin  (C3H/HeJ x C57BL/6J)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The mouse amyloid beta (A4) precursor protein (App) sequence was first modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (called mo/huAPP695 or APP695) was further mutated to incorporate the Swedish (K595M/N596L) mutation associated with Alzheimer's disease. This APP695Swe/Ind sequence was placed downstream of the brain-specific mouse prion promoter (Prnp). The first transgene was co-integrated with a second transgene in which the mouse prion promoter promoter drives expression of a mutant human presenilin 1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease.
  • mutations:
  • Insertion
  • synonyms:
  • D-943,
  • D-943
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1 Feature

Trail: Allele

Genome

2 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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3 Publication categories

Trail: Allele




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