| Primary Identifier | MGI:7543840 | Allele Type | Targeted |
| Gene | Itpr1 | Transmission | Germline |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A GAC to AAA change resulting in an aspartate to lysine substitution at amino acid 2594 (p.D2594K) was introduced in the channelâs gating domain. The inserted FRT-flanked neomycin selection cassette was removed via flp-mediated recombination. This mutation increases the sensitivity of IP3-induced calcium release and is a gain-of-function allele. |
