| Primary Identifier | MGI:7532630 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Reln |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Histidine codon 3448 (CAC) in exon 64 was changed to arginine (CGT) (p.H3448R) and a neomycin resistance gene cassette flanked by self-deletion anchor sites was inserted into intron 64. The mutation is the equivalent of the human p.H3447R mutation associated with resilience to autosomal dominant Alzheimerâs disease (ADAD). |
