| Primary Identifier | MGI:7529114 | Allele Type | Targeted |
| Gene | Pten | Transmission | Germline |
| Strain of Origin | C57BL/6NTac | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Tyrosine codon 138 (TAT) in exon 5 was changed to leucine (TTG) (p.Y138L) and an FRT site flanked puromycin resistance gene cassette was inserted into intron 4. The puro cassette was removed through subsequent Flp-mediated recombination. The mutation leads to the encoded protein lacking protein phosphatase activity while leaving lipid phosphatase activity intact. |
