| Primary Identifier | MGI:7518551 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Lmna |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Arginine codon 133 (CGG) in exon 2 was changed to leucine (CTG) (p.R133L) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the same human mutation associated with atypical progeria syndrome (APS). |
