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Allele : Gt(ROSA)26Sor<tm2(CAG-Egfr*L860R)Rnem> gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Raphael A Nemenoff
Primary Identifier  MGI:7545201 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  C57BL/6N-A<tm1Brd>
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting cassette includes (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), a loxP-flanked STOP cassette including neomycin sequence, Egfr mutant cDNA (L860R mutation), mCerulean3 (mC3) sequence, a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability), and polyA signal. This targeting vector was inserted into intron 1 of the Gt(ROSA)26Sor locus. The murine L860R mutation corresponds to the human L858R mutation.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Egfr<L860R>,
  • Egfr<L860R>
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1 Feature

Trail: Allele

Genome

1 Expresses

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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