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Allele : Prnp<em2Chjs> prion protein; endonuclease-mediated mutation 2, Christina J Sigurdson

Primary Identifier  MGI:7548889 Allele Type  Endonuclease-mediated
Gene  Prnp Strain of Origin  (C57BL/6 x SJL)F1 x C57BL/6NJ
Is Recombinase  false Is Wild Type  false
molecularNote  Threonine codon 187 (ACG) in exon 3 was changed to asparagine (p.T187N) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation adds a third glycosylation site (in addition to N180 and N196) to the encoded peptide.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Prnp<187N>,
  • Prnp<187N>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories

Trail: Allele