| Primary Identifier | MGI:7564596 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Scn10a |
| Transmission | Germline | Strain of Origin | C57BL/6NCrl |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Glycine codon 1663 (GGC) in exon 28 was changed to serine (AGC) (p.G1663S) and a loxP site, a neomycin resistance gene cassette, a cre gene cassette and a second loxP site were inserted into intron 27. The neo and cre cassettes auto-excised. The mutation is the equivalent of the human p.G1662S gain-of-function mutation associated with idiopathic painful small fiber neuropathy (SFN). |
