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Allele : Htra1<tm1.2(UBC-ARMS2)Hohj> HtrA serine peptidase 1; targeted mutation 1.2, Josephine Hoh
Primary Identifier  MGI:7565419 Allele Type  Targeted
Attribute String  Humanized sequence, Hypomorph, Inserted expressed sequence Gene  Htra1
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector is designed to insert a human ubiquitin C promoter, a loxP-flanked STOP cassette, a human ARMS2 cDNA tagged with a Flag epitope, and an FRT-flanked neomycin cassette upstream of the Htra1 promoter. Mice do not have the ARMS2 gene. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed the STOP cassette. The expression of endogenous Htra1 in the cortex is decreased by 22% in early adult mice.
  • mutations:
  • Insertion
  • synonyms:
  • ARMS2<tm1jhoh>,
  • ARMS2<tm1jhoh>
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1 Feature

Trail: Allele

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1 Expresses

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0 Mutation Involves

Phenotype

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Trail: Allele




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