| First Author | Barone I | Year | 2023 |
| Journal | Sci Adv | Volume | 9 |
| Issue | 43 | Pages | eadj1010 |
| PubMed ID | 37878694 | Mgi Jnum | J:342247 |
| Mgi Id | MGI:7546442 | Doi | 10.1126/sciadv.adj1010 |
| Citation | Barone I, et al. (2023) Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity. Sci Adv 9(43):eadj1010 |
| abstractText | The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on the BMAL1 transcription factor. We report that BMAL1 rhythmically localizes to hippocampal synapses in a manner dependent on its phosphorylation at Ser(42) [pBMAL1(S42)]. pBMAL1(S42) regulates the autophosphorylation of synaptic CaMKIIalpha and circadian rhythms of CaMKIIalpha-dependent molecular interactions and LTP but not global rest/activity behavior. Therefore, our results suggest a model in which repurposing of the clock protein BMAL1 to synapses locally gates the circadian timing of plasticity. |
