| Primary Identifier | MGI:7547459 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Adar |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Proline codon 195 (CCT) in exon 2 was targeted for change to alanine (GCT) (p.P195A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This allele represents an unintended deletion event where a single T nucleotide in exon 2 was deleted (c.587delT), resulting in a frameshift and premature stop codon (p.L196Cfs*7); the P195 codon did not change. This mutation affects the translation of the p150 isoform but not the p110 isoform. |
