| Primary Identifier | MGI:7548531 | Allele Type | Endonuclease-mediated |
| Gene | Btk | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Cysteine codon 481 (TGC) in exon 15 was changed to serine (TCC) (p.C481S) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation renders the encoded peptide insensitive to B-cell proliferation and survival inhibitor ibrutinib. |
