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Allele : Tc(HSA19*APOE_i4)1Mdk transchromosomal, human 19, line 1, Michael Koob; transchromosomal, human 19, line 1, Michael D Koob
Primary Identifier  MGI:7565468 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tc(HSA19*APOE_i4)1Mdk
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  A 30 kb deletion on mouse chromosome 7 stretching from, Apoe to Apoc is replaced by a syntenic 47 kb region from human chromosome 19 (HSA19). The mouse Apoe (apoliprotein e) isoform 4 and Apoc (apolipoprotein C) genes are replaced by human APOE (isoform E4) and APOC genes. A loxP-flanked neomycin resistance cassette is included in the construct. The neomycin cassette was removed by transient expression of cre.
  • mutations:
  • Intergenic deletion,
  • Insertion
  • synonyms:
  • APOE4-GR,
  • APOE4-GR
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1 Feature

Trail: Allele

Genome

4 Expresses

Trail: Allele

4 Mutation Involves

Trail: Allele

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

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Trail: Allele




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