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Allele : Apoe<em1(APOE_i4*)Yhg> apolipoprotein E; endonuclease-mediated mutation 1, Yadong Huang
Primary Identifier  MGI:7565501 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Apoe
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
description  Zygotes used for targeting were generated by mating superovulated C57BL/6 females to Apoetm3(APOE_i4)Yhg males.
molecularNote  CRISPR/Cas9 technology introduced a C-to-A change resulting in an arginine to serine substitution at amino acid 136 (p.R136S) in the inserted human APOE isoform 4 of the Apoetm3(APOE_i4)Yhg allele.
  • mutations:
  • Single point mutation
  • synonyms:
  • APOE4-R136S-KI,
  • APOE4-R136S-KI
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1 Feature

Trail: Allele

Genome

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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