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Allele : Il6<em1(IL6)Akp> interleukin 6; endonuclease-mediated mutation 1, Karolina Palucka
Primary Identifier  MGI:7628228 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Il6
Strain of Origin  NOD.Cg-Flt3<em1Akp> Prkdc<scid> Il2rg<tm1Wjl>/J Is Recombinase  false
Is Wild Type  false
molecularNote  Using a CRISPR/Cas9 system, Cas9 mRNA, sgRNAs targeting mouse Il6 and recombinant human IL6 genomic DNA were co-injected into fertilized NOD.Cg-Flt3em1Akp Prkdcscid Il2rgtm1Wjl/J oocyte. Full-length human IL6 sequence replaces exons 1-5 of the mouse Il6 gene.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Il6<emX(IL6)Akp>,
  • Il6<emX(IL6)Akp>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

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0 Driven By

2 Publication categories

Trail: Allele




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