| Primary Identifier | MGI:7550435 | Allele Type | Targeted |
| Attribute String | Conditional ready, Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | C57BL/6 and 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A beta-actin promoter and loxP-flanked TK-Neo STOP cassette followed by the Polb gene containing a leucine to proline substitution at amino acid 22 (p.L22P, CTC to CCC) were inserted into the locus. This mutation results in loss of 5â-deoxyribose-5-phosphate lyase activity and inefficient base excision repair. The p.L22P variant is associated with gastric cancer in humans. This line is generated from ES clone 89. |
