| Primary Identifier | MGI:7567375 | Allele Type | Targeted |
| Gene | Mecp2 | Transmission | Germline |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Serine codons 86 in exon 3 (TCC) and 274 (AGT) and 421 (TCA) in exon 4, and threonine codon 308 (ACC) in exon 4 were changed to alanine (GCT, GCT, GCA, GCC) (p.S86A, p.S274A, p.S421A, p.T308A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 3. The neo cassette was removed through subsequent Cre-mediated recombination. The mutations prevent activity-induced phosphorylation of the affected residues in the encoded peptide. |
