| Primary Identifier | MGI:7572876 | Allele Type | Endonuclease-mediated |
| Attribute String | Dominant negative, Humanized sequence | Gene | Etv6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Proline codon 216 (CCA) in exon 5 was changed to leucine (CTA) (p.P216L) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.P214L (c.641C>T) mutation associated with the autosomal dominant syndrome of thrombocytopenia and leukemia predisposition. |
