| First Author | Cui X | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 8 | Pages | 110398 |
| PubMed ID | 35196493 | Mgi Jnum | J:328356 |
| Mgi Id | MGI:6881881 | Doi | 10.1016/j.celrep.2022.110398 |
| Citation | Cui X, et al. (2022) Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory. Cell Rep 38(8):110398 |
| abstractText | CaMKII has long been known to be a key effector for synaptic plasticity. Recent studies have shown that a variety of modulators interact with the subunits of CaMKII to regulate the long-term potentiation (LTP) of hippocampal neurons. However, whether long non-coding RNAs modulate the activity of CaMKII and affect synaptic plasticity is still elusive. Here, we identify a previously uncharacterized long non-coding RNA Carip that functions as a scaffold, specifically interacts with CaMKIIbeta, and regulates the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) receptor subunits in the hippocampus. The absence of Carip causes dysfunction of synaptic transmission and attenuates LTP in hippocampal CA3-CA1 synapses, which further leads to impairment of spatial learning and memory. In summary, our findings demonstrate that Carip modulates long-term synaptic plasticity by changing AMPA receptor and NMDA receptor activities, thereby affecting spatial learning and memory in mice. |
