| Primary Identifier | MGI:7576962 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence, Null/knockout | Gene | Psen1 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The targeting vector is designed to insert a 106 kb (Chr14:73121400 - 73227703) fragment of the human PSEN1 in place of Chr12:83730110 - 83793335 of the mouse Psen1 gene. The construct includes an loxP-flanked neomycin selection cassette. In addition, there is also a PSEN1-DT (non-coding antisense RNA) in the human genome segment. The insertion disrupts Psen1 transcription. The neomycin cassette was removed by transient expression of cre. |
