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Allele : Tnnc1<tm1.1Svbt> troponin C, cardiac/slow skeletal; targeted mutation 1.1, Svetlana B Tikunova
Primary Identifier  MGI:7580682 Allele Type  Targeted
Gene  Tnnc1 Transmission  Germline
Strain of Origin  129S/SvEv Is Recombinase  false
Is Wild Type  false
molecularNote  Aspartic acid codon 73 (GAC) in exon 4 was changed to asparagine (AAC) (p.D73N) and a FRT site flanked neomycin resistance gene cassette was inserted into intron 4. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation, in the second Ca<2+>-binding loop of the encoded peptide, desensitizes the peptide to Ca<2+>.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • D73N<+>,
  • D73N<+>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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