| Primary Identifier | MGI:7621479 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A CAG::loxP::transcriptional stop sequence::loxP::STING*N153S cassette was introduced to the mouse Gt(ROSA)26Sor gene using transcription activator-like effector nucleases (TALENs). The STING N153S mutation incorporates a AAT to TCT nucleotide change in exon 5 that results in an amino acid substitution at position 153. The STING N153S mutation is analogous to the N154S mutation in human TMEM173. N154S is associated with (STING)-associated vasculopathy with onset in infancy (SAVI). |
