| Primary Identifier | MGI:7611836 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence, Null/knockout | Gene | Gne |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Proline codon 735 (CCG) in exon 12 was changed to arginine (CGG) (c.2204C>G:p.P735R) using sgRNAs and an ssODN template with CRISPR/Cas9 technology. The mutation, in the N-acetylmannosamine (ManNAc) kinase domain of the encoded peptide, is the equivalent of the same human mutation associated with macrothrombocytopenia. |
