| Primary Identifier | MGI:7641517 | Allele Type | Endonuclease-mediated |
| Gene | Tet1 | Strain of Origin | C57BL/6J x DBA/2J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Threonine codon 1642 (ACC) in exon 11 was changed to valine (GTC) (p.T1642V) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation changes the catalytic activity of the encoded peptide so that it oxidizes 5mC to 5-hydroxymethyl-cytosine (5hmC) but no further. |
