| Primary Identifier | MGI:7616511 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence | Gene | Tubg1 |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Tyrosine codon 92 (TAC) in exon 3 was changed to cysteine (TGC) (c.275A>G:). A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and second loxP site were inserted into intron 3 The neo cassette was removed through subsequent Flp-mediated recombination, leaving exon 2-3 floxed. The mutation is the equivalent of the same human mutation associated with complex cortical dysplasia with other brain malformations 4 (CDCBM4). |
