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Allele : Prkca<em1New> protein kinase C, alpha; endonuclease-mediated mutation 1, Alexandra C Newton

Primary Identifier  MGI:7642206 Allele Type  Endonuclease-mediated
Gene  Prkca Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR/cas9 mediated recombination inserted an A to G substitution creating a Met to Val mutation at position 489. The amino acid substitution increases agonist evoked signaling output by the protein.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • PKCalha-M489V,
  • PrkcaM489V,
  • PKCalha-M489V,
  • PrkcaM489V
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories

Trail: Allele