Primary Identifier | MGI:7642206 | Allele Type | Endonuclease-mediated |
Gene | Prkca | Strain of Origin | C57BL/6NTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | CRISPR/cas9 mediated recombination inserted an A to G substitution creating a Met to Val mutation at position 489. The amino acid substitution increases agonist evoked signaling output by the protein. |