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Allele : Nlrp3<em1Helin> NLR family, pyrin domain containing 3; endonuclease-mediated mutation 1, Hening Lin

Primary Identifier  MGI:7645401 Allele Type  Endonuclease-mediated
Gene  Nlrp3 Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  Cysteine codon 126 (TGT) in exon 3 was changed to alanine (GCA) (p.C126A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks palmitoylation of the affected residue in the encoded peptide.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • NLRP3 C126A,
  • NLRP3 C126A
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories

Trail: Allele