Primary Identifier | MGI:7645401 | Allele Type | Endonuclease-mediated |
Gene | Nlrp3 | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Cysteine codon 126 (TGT) in exon 3 was changed to alanine (GCA) (p.C126A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks palmitoylation of the affected residue in the encoded peptide. |