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Allele : Trpv1<em1Yeyu> transient receptor potential cation channel, subfamily V, member 1; endonuclease-mediated mutation 1, Ye Yu

Primary Identifier  MGI:7645436 Allele Type  Endonuclease-mediated
Gene  Trpv1 Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  Threonine codon 634 (ACA) in exon 13 was changed to alanine (GCA) (p.T634A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks the proton-evoked (low pH) activation of the encoded peptide.
  • mutations:
  • Single point mutation
  • synonyms:
  • Trpv1<T634A>,
  • Trpv1<T634A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories

Trail: Allele