| Primary Identifier | MGI:7647023 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Sting1 |
| Strain of Origin | C57BL/6NJ | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Valine codon 154 (GTT) in exon 5 was changed to methionine (ATG) (p.) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation, located in the dimerization domain (DD) of the encoded peptide, is the equivalent of the human p.V155M mutation associated with STING-associated vasculopathy with onset in infancy (SAVI). |
