| Primary Identifier | MGI:7657210 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Apc |
| Inheritance Mode | Not Specified | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The Apc gene is located on chromosome 18 in mice and contains a total of 16 exons. Gene editing technology is used to knock out a portion of the exon 16 of this gene. This exon occupies more than 70% of the coding region of the Apc gene and includes the mutation cluster region (MCR) corresponding to high-frequency mutations in human diseases. This strain is homozygous lethal. Heterozygous Apc KO mice can spontaneously develop intestinal adenomas and exhibit significant colorectal cancer disease phenotypes in various aspects such as survival, growth, food intake, and intestinal lesions. Therefore, Apc KO mice can be used for familial adenomatous polyposis (FAP) and colorectal cancer and other tumors or tumor-related diseases, as well as the study of the regulatory mechanism of the Wnt/β-catenin signaling pathway. |
