| Primary Identifier | MGI:7707802 | Allele Type | Endonuclease-mediated |
| Attribute String | Modified regulatory region | Gene | Rr504 |
| Strain of Origin | (C57BL/6 x DBA/2)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The mouse equivalent of of the XY sex reversal region (XYSR) found in human patients with disorders of sexual development (a 32.5 kb sequence located far upstream of SOX9), containing an embryonic Sox9 testis enhancer, was targeted using sgRNAs (equivalent to GAAGCTGCCTCGGGGAATA and ATGGACAAATGGCGTTTAT) with CRISPR/Cas9 technology, resulting in a 26,850 bp deletion (GRCm39:chr11:112105956-112132805) encompassing the entire sequence. This allele leads to sex reversal (genetic males present as phenotypic females). |
