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Allele : Igk<em2Abtx> immunoglobulin kappa chain complex; endonuclease-mediated mutation 2, Dan Rohrer
Primary Identifier  MGI:7715232 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Igk
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  The allele has the mouse immunoglobulin kappa chain complex (Igk) region variable (V) and joining (J) segments deleted. Specifically, CRISPR/Cas9 genome editing in 129S6/SvEvTac-derived CMTI-1 embryonic stem (ES) cells was used to remove a ~3.2 Mb sequence including the mouse Igk V and J segments and replace it with a PGK-neomycin resistance cassette.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • KLaP (k-KO),
  • KLaP (k-KO)
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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