| First Author | Oura S | Year | 2022 |
| Journal | PLoS Genet | Volume | 18 |
| Issue | 6 | Pages | e1010241 |
| PubMed ID | 35648791 | Mgi Jnum | J:325726 |
| Mgi Id | MGI:7287152 | Doi | 10.1371/journal.pgen.1010241 |
| Citation | Oura S, et al. (2022) Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. PLoS Genet 18(6):e1010241 |
| abstractText | Meiosis is a hallmark event in germ cell development that accompanies sequential events executed by numerous molecules. Therefore, characterization of these factors is one of the best strategies to clarify the mechanism of meiosis. Here, we report tripartite motif-containing 41 (TRIM41), a ubiquitin ligase E3, as an essential factor for proper meiotic progression and fertility in male mice. Trim41 knockout (KO) spermatocytes exhibited synaptonemal complex protein 3 (SYCP3) overloading, especially on the X chromosome. Furthermore, mutant mice lacking the RING domain of TRIM41, required for the ubiquitin ligase E3 activity, phenocopied Trim41 KO mice. We then examined the behavior of mutant TRIM41 (DeltaRING-TRIM41) and found that DeltaRING-TRIM41 accumulated on the chromosome axes with overloaded SYCP3. This result suggested that TRIM41 exerts its function on the chromosome axes. Our study revealed that Trim41 is essential for preventing SYCP3 overloading, suggesting a TRIM41-mediated mechanism for regulating chromosome axis protein dynamics during male meiotic progression. |
