Primary Identifier | MGI:7790880 | Allele Type | Endonuclease-mediated |
Attribute String | Modified regulatory region | Gene | Rr588 |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The Cyp24a1 renal super-enhancer containing vitamin-D-response-elements, located downstream, was targeted using sgRNAs (equivalent to TAGGGACAAGGCATCAGACGAGG and AGAGTCGAGCGGAAATGTGCAGG) with CRISPR/Cas9 technology, resulting in an ~17.5 kb deletion. |