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Allele : Apoe<em4(APOE*)Msasn> apolipoprotein E; endonuclease-mediated mutation 4, Michael Sasner

Primary Identifier  MGI:7703589 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Apoe
Strain of Origin  B6.Cg-Apoe<em2(APOE*)Adiuj>/J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 genome editing methodologies were used to introduce p.R136S (Christchurch) point mutations in the human APOE (APOE isoform E3) carried by the Apoeem2(APOE*)Adiuj allele which has the p.R130C point mutation in the human APOE protein.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

2 Publication categories

Trail: Allele