| First Author | Chang B | Year | 2024 |
| Journal | MGI Direct Data Submission | Mgi Jnum | J:351808 |
| Mgi Id | MGI:7703896 | Citation | Chang B (2024) The Grm6 |
| abstractText | The spontaneous mutation nob3-3J was discovered in our ocular phenotypes screening program in August 2010 in male mouse of B6;C3-Tg(FOXJ1-EGFP)85Leo/J (JAX Stock No. 010827) that presented with no cone ERG responses, but the female mouse had normal cone ERG responses at 4 weeks of age. We mated the male mutant mouse with C57BL/6J and all F1 mice had normal cone ERG responses. Linkage crosses then showed this spontaneous mutation to be an autosomal recessive mutation that mapped to Chromosome 11 in the same location as the Grm6 gene. Then we tested this new no cone ERG responses for rod ERG and rod ERG showed that this new mutant also had a normal rod ERG a-wave but no rod ERG b-wave. we did a complementation test between this new mutation and nob3 homozygotes and they failed to complement proving them allelic. We named the new no b-wave Grm6nob3-3J and moved it further onto the C57BL/6J background with 2 cycles of backcross-intercross breeding during which the Tg(FOXJ1-EGFP)85Leo was bred out of the line, B6;C3-Grm6nob3-3J/Boc (JAX Stock No. 035327), which was sibling inbred to homozygosity. |
