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Allele : Rr485<em1Mam> regulatory region 485; endonuclease-mediated mutation 1, Lothar Hennighausen

Primary Identifier	MGI:7664601	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr485
Strain of Origin	C57BL/6N	Is Recombinase	false
Is Wild Type	false

molecularNote

The casein gene cluster super-enhancer, containing enhancers Rr486, Rr487, Rr488 and Rr489, was deleted using sgRNAs (equivalent to CGCTAAGCATGTAGGGTCTCAGG and TGGGTGTTCTTCCACTAGACAGG) with CRISPR/Cas9 technology, resulting in a 9049 bp deletion.

mutations:
Intergenic deletion

synonyms:
deltaSE,
deltaSE

earliestPublication:
Lee HK, et al. (2023) Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands. Nat Commun 14(1):4992

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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