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Allele : App<em7Msasn> amyloid beta precursor protein; endonuclease-mediated mutation 7, Michael Sasner
Primary Identifier  MGI:7703876 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  App
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  Using CRISPR/Cas9 technology, the humanizing A(beta) region R684H, F681Y, and G676R mutations, and the KM670/671NL (Swedish) mutation, as well as the E693Q (Dutch) and D694N (Iowa) mutations were introduced in the mouse App (amyloid beta (A4) precursor protein) gene.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • APP<SDI>,
  • APP<SDI>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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Trail: Allele

0 Driven By

2 Publication categories

Trail: Allele




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