Primary Identifier | MGI:7738390 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Mafb |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Using CRISPR/Cas9 endonuclease-mediated genome editing, guide RNAs (TGGCCGCGGAGCTGAGCATG and TGCGGGCGGCAACGGTAGTG) were selected to excise and replace murine amino acids 5-202 in exon 1 of the MAF bZIP transcription factor B (Mafb) gene, on chromosome 2, with human wildtype amino acids 5-202 of MAFB (MAFB-201; ENST00000373313.3) exon 1. |