| First Author | Costantini TW | Year | 2022 |
| Journal | Inflamm Res | Volume | 71 |
| Issue | 1 | Pages | 9-11 |
| PubMed ID | 34792616 | Mgi Jnum | J:353277 |
| Mgi Id | MGI:7710045 | Doi | 10.1007/s00011-021-01519-1 |
| Citation | Costantini TW, et al. (2022) CHRFAM7A expression in mice increases resiliency after injury. Inflamm Res 71(1):9-11 |
| abstractText | INTRODUCTION: The CHRNA7 gene encodes the alpha-7 nicotinic acetylcholine receptor (alpha7nAchR) that regulates anti-inflammatory responses to injury; however, only humans express a variant gene called CHRFAM7A that alters the function of alpha7nAChR; CHRFAM7A expression predominates in bone marrow and monocytes/macrophages where the CHRFAM7A/CHRNA7 ratio is highly variable between individuals. We have previously shown in transgenic mice that CHRFAM7A increased emergency myelopoiesis from the bone marrow and monocyte/macrophage expression in lungs. MATERIALS AND METHODS: CHRFAM7A transgenic mice are compared to age- and gender-matched wild-type (WT) siblings. We utilized a model of sepsis using LPS injection to measure survival. Lung vascular permeability was measured after severe burn injury in WT vs. CHRFAM7A transgenic mice. Bone marrow CHRFAM7A expression was evaluated using adoptive transfer of CHRFAM7A transgenic bone marrow into WT mice. RESULTS: Here, we demonstrate that CHRFAM7A expression results in an anti-inflammatory phenotype with an improved survival to LPS and decreased acute lung injury in a severe cutaneous burn model compared to WT. CONCLUSIONS: These data suggest that the relative expression of CHRFAM7A may alter resiliency to injury and contribute to individual variability in the human systemic inflammatory response (SIRS) to injury. |
