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Allele : Gt(ROSA)26Sor<tm1.1(CAG-APOBEC1/YTHDF2)Kmey> gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Kate D Meyer
Primary Identifier  MGI:7783572 Allele Type  Targeted
Attribute String  Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (129S6/SvEvTac x C57BL/6NCrl)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting construct consists of a CAG (CMV enhancer/chicken beta-actin) promoter, a loxP-flanked STOP cassette, a rat apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) sequence fused to a human YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) sequence, followed by an HA tag, a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE), a BGH polyA signal, and an attB/attP-flanked PGK-FRT-Neo-polyA cassette was inserted into the GT(ROSA)26Sor locus. FLP-recombinase removed the neo cassette.
  • mutations:
  • Insertion
  • synonyms:
  • APOBEC1-YTH,
  • APOBEC1-YTH
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0 Mutation Involves

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