| Primary Identifier | MGI:7790505 | Allele Type | Endonuclease-mediated |
| Attribute String | Modified regulatory region | Gene | Rr584 |
| Strain of Origin | 129 x C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The Satb1 IL4-responsive TH2-specific enhancer was targeted using sgRNAs (equivalent to GGATTGAAGTGTTCGCATGT and CAGTCAACATCAGAATTTCT) with CRISPR/Cas9 technology, resulting in an 828 bp deletion (GRCm39:chr17:52469270-52470097). This allele was created in ES cells carrying the Satb1tm1Itan allele on the paternal chromosome and mice carrying the two alleles on the same chromosome were selected. |
