| First Author | Ohnaka Y | Year | 2023 |
| Journal | Biochem Biophys Res Commun | Volume | 681 |
| Pages | 73-79 | PubMed ID | 37757669 |
| Mgi Jnum | J:357891 | Mgi Id | MGI:7542602 |
| Doi | 10.1016/j.bbrc.2023.09.059 | Citation | Ohnaka Y, et al. (2023) Bradykinin deficiency causes high blood pressure in mice. Biochem Biophys Res Commun 681:73-79 |
| abstractText | Bradykinin has a wide variety of physiological functions, including vasodilation and blood pressure reduction. However, the physiological roles of bradykinin are not fully understood. We used the CRISPR/Cas9 method to generate BK(del)K1 and BK(del)K2 mutant mice, targeting the BK portion of mouse kininogen1 and kininogen2 genes, respectively. The BK(del)K1 and BK(del)K2 mutant mice had about 50% reductions in plasma low molecular weight kininogen and trypsin-released BK, compared to wild mice. Both BK(del)K1 and BK(del)K2 mice had significantly elevated systolic blood pressure compared to WT mice. These results suggest that plasma LKNG is a source of KNG in the vascular kallikrein-kinin system and contributes to maintaining lower systolic blood pressure. |
