| Primary Identifier | MGI:7856726 | Allele Type | Endonuclease-mediated |
| Attribute String | Modified regulatory region | Gene | Rr544 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Taar enhancer TE1, located between Taar1 and Taar2, was targeted using sgRNAs (targeting TGGTTGTGAGTTGCTTGTGG, TCAGCCTGTTAATTACCTGA, AGAACTTTCAGAGAGTTCCC, GAACCCAGAACTGACTTTTG, TATTCTAGAAATACAGATGT and AGCATCCTGGAGGTGAAATG) with CRISPR/Cas9 technology, resulting in a 1372 bp deletion (GRCm39:chr10:23805780-23807151). This leads to the reduction in expression of most Taar genes without affecting olfactory gene expression. |
