| Primary Identifier | MGI:7856664 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Del(17Airn)1Arge |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| description | This allele was made by chromosome engineering by targeted meiotic recombination (Herault et al 1998), by breeding together the Airn truncation allele (Sleutels et al 2002 Nature) and the Igf2r promoter deletion (Sleutels et al 2003 EMBO J.) with Hprt-Cre (Tang et al 2002 Genesis), and screening the offspring of triple mutant males for recombination events. |
| molecularNote | The allele has a 28kb deletion on chromosome 17 between 3kb downstream of the Airn transcription start site (TSS) (Igf2r intron 2) and 2.8kb upstream of the Igf2r TSS (GRCm38/mm10, chr17: 12,744,358 -12,772,513). Additionally, Airn is truncated by a polyadenylation cassette immediately before the AIDel deletion. |
