| Primary Identifier | MGI:7858944 | Allele Type | Endonuclease-mediated |
| Attribute String | Modified regulatory region | Gene | Rr381 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A 34 bp region in the Zbtb7b silencer, containing conserved Runx-binding motifs in addition to several predicted EGR, Ebox, and NFAT-binding sites, was targeted with a dsODN template using TALEN technology (ZFN target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG), resulting in its replacement with the equivalent 34 bp sequence from Cd4 silencer Rr96. |
