Primary Identifier | MGI:7858952 | Allele Type | Endonuclease-mediated |
Attribute String | Modified regulatory region | Gene | Rr381 |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The Zbtb7b silencer, located upstream, was targeted with a dsODN template using TALEN technology (ZFN target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG), resulting in the mutation of two EGR (E6, E7) binding sites and one Ebox (T6) motif. |